Female reproductive & breastCancerICD-10 C54
Endometrial (womb) cancer
Also called: Uterine cancer
Cancer of the womb lining, most often after menopause. Because it usually causes early bleeding, it is frequently caught at a curable stage.
Condition-specific references are below. Individual claims and this page have not been clinically reviewed. Read about this content.
Causes
- Unopposed oestrogen stimulation of the endometrium; genetic factors
Risk factors
- Obesity
- Unopposed oestrogen HRT
- Tamoxifen
- PCOS
- Diabetes
- Lynch syndrome
- Never having children
Symptoms
- Bleeding after menopause
- Irregular heavy bleeding before menopause
- Watery discharge
Diagnosis — tests and examinations
- Transvaginal ultrasound (endometrial thickness)
- Endometrial biopsy or hysteroscopy
- MRI staging
Treatment
Medicines and medical treatment
- Radiotherapy/brachytherapy
- Chemotherapy and immunotherapy for advanced disease
- Progestogens for fertility-sparing treatment
Operations and procedures
- Total hysterectomy with removal of tubes and ovaries (usually laparoscopic)
Self-care, home remedies and lifestyle
- Weight loss
Possible complications
- Spread to pelvic lymph nodes
Prevention
- Healthy weight, progestogen with oestrogen HRT
Outlook
About 80% five-year survival overall; higher when early.
When to see a doctor
Any bleeding after menopause needs prompt assessment.
Sources and further reading
These sources cover this condition. They have not been checked against every statement on this page.
Related conditions
Educational overview, not medical advice. Treatment varies by person and location. Consult a qualified health professional for diagnosis or care. Read our content and model notes and privacy information.